将两个高转移性人肺腺癌细胞系分别经腹腔、静脉和皮下接种于裸小鼠。其肺转移癌可按局部解剖学分为5型。各型出现的频度与接种途径及癌细胞系的不同有关。提示了转移性癌细胞在靶器官内的分布具有组织空间的偏向性,以及生长环境可修饰肿瘤细胞的生物学特性。 Two highly metastatic human lung adenocarcinoma cell lines were inoculated intraperitoneally, intravenously, and subcutaneously in nude mice. The lung metastatic cancer can be divided into 5 types according to the local anatomy. The frequency of occurrence of each type is related to the difference in the route of vaccination and the cancer cell line. It is suggested that the distribution of metastatic cancer cells in the target organ has a spatial bias in the tissue space, and the growth environment can modify the biological characteristics of the tumor cells.