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应用半乳糖-半乳糖胺检测法对118份直肠粘液标本作了检查。在30例大肠癌病人中其阳性率达90％,在65例肠粘膜正常人中,其阴性率达92.3％;另外20例大肠息肉病人中,其阳性率为15％,3例溃疡性结肠炎病人中阳性率为66.7％。结果表明:该法有较高的敏感性(90％)和特异性(92.3％),方法简便,结果易重复,在大肠癌普查中具有较大的应用潜力;在大肠息肉和溃疡结肠性炎中也有一定的阳性率,提示该法可用于某些大肠癌癌前状态恶变的监测。
The galactose-galactosamine assay was used to examine 118 rectal mucin specimens. Among the 30 patients with colorectal cancer, the positive rate was 90%. In 65 normal people with intestinal mucosa, the negative rate was 92.3%; in 20 patients with colorectal polyps, the positive rate was 15%, and 3 cases had ulcerative colon. The positive rate in inflammatory patients was 66.7%. The results showed that the method has high sensitivity (90%) and specificity (92.3%). The method is simple, the results are easily reproducible, and it has great application potential in the screening of colorectal cancer; in colorectal polyps and ulcer colitis It also has a certain positive rate, suggesting that this method can be used to monitor the premalignant status of certain colorectal cancers.