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目的 :探讨脐血联合 Mx AE方案治疗难治性急非淋白血病的效果。方法 :脐血联合 Mx AE方案治疗难治性急非淋白血病 2 1例 ,难治性 14例 ,复发性 7例。治疗方案 :米托蒽醌 ( Mx) 10 m g/ d、l d～ 3 d;阿糖胞苷( Ara- C) 15 0 mg/ d,l d～ 7d;足叶乙式 ( VP1 6) 10 0 mg/ d,l d～ 5 d。3种药物均静滴 ,3 d～ 7d为一疗程。化疗第 1周、第 2周输脐血 ,每周 3个～ 5个单位。结果 :完全缓解率 ( CR) 66.7% ,骨髓抑制 18例。化疗第 2周、第 3周 ,WBC>3 .0× 10 9/ L ,Plt>5 0× 10 9/ L分别为 16例、2例。无化疗相关死亡。食欲恢复快 ,骨髓抑制期短。结论 :脐血辅助Mx AE方案是基层医院治疗难治性急非淋白血病的有效方法
Objective: To investigate the effect of umbilical cord blood combined with Mx AE in the treatment of refractory acute non-leukemia. Methods: Umbilical cord blood combined with Mx AE regimen in the treatment of refractory acute leukemia 21 cases, refractory in 14 cases, recurrent in 7 cases. Treatment regimen: Mitoxantrone (Mx) 10 mg / d, ld ~ 3 d; Ara-C 150 mg / d, / d, ld ~ 5 d. 3 kinds of drugs are intravenous infusion, 3d ~ 7d for a course of treatment. The first week of chemotherapy, the second week of cord blood, 3 to 5 units per week. Results: The complete remission rate (CR) 66.7%, bone marrow suppression in 18 cases. In the second and third weeks of chemotherapy, WBC> 3.0 × 10 9 / L and Plt> 50 × 10 9 / L were 16 and 2 respectively. No chemotherapy-related death. Fast appetite recovery, bone marrow suppression period is short. Conclusion: Cord blood-assisted Mx AE regimen is an effective method for treatment of refractory acute non-leukemia in primary hospitals