Due to the interrelationship between the base placement of the manipulator and its operation object,it is significant to analyze the accessibility and workspace of manipulators for the optimization of their base location.A new method is presented to optimize the base placement of manipulators through motion planning optimization and location optimization in the feasible area for manipulators.Firstly,research problems and contents are outlined.And then the feasible area for the manipulator base installation is discussed.Next,index depended on the joint movements and used to evaluate the kinematic performance of manipulators is defined.Although the mentioned indices in last section are regarded as the cost function of the latter,rapidly-exploring random tree(RRT) and rapidly-exploring random tree*(RRT*) algorithms are analyzed.And then,the proposed optimization method of manipulator base placement is studied by means of simulation research based on kinematic performance criteria.Finally,the conclusions could be proved effective from the simulation results. Due to the interrelationship between the base placement of the manipulator and its operation object, it is significant to analyze the accessibility and workspace of manipulators for the optimization of their base location. A new method is presented to optimize the base placement of manipulators through motion planning optimization and location optimization in the feasible area for manipulators. Firstly, research problems and contents are outlined. And then then the feasible area for the manipulator base installation is discussed .Next, index depended on the joint movements and used to evaluate the kinematic performance of manipulators is defined. Though the mentioned indices in the last sections are regarded as the cost function of the latter, rapidly-exploring random tree (RRT) and rapidly-exploring random tree * (RRT *) algorithms are analyzed. And then then, the proposed optimization method of manipulator base placement is studied by means of simulation research based on kinematic performance criteria. Finaally, the conclusions could be proved effective from the simulation results.