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应用文献计量学方法分析１９８８～１９９７年间４２个国家发表的４７８３篇基因治疗研究文献的动态变化。１０年来的基因治疗研究文献呈快速增长趋势，英文文献占全部基因治疗文献的８７．８７％，美国和英国是当前世界上发表基因治疗研究文献最多的国家；占被索文献总量４０．３４％的２３种期刊被初步确定为基因治疗研究的核心期刊；基因治疗方法学和发展趋势是当前基因治疗研究的主要内容，其治疗方法与传统药物治疗的区别正在缩小，在确保载体进入特定的细胞类型方面已经取得了相当的进展，但是，导入人体的目的基因表达水平低和获得长期表达效果难的问题仍是影响治疗效果、限制基因治疗临床应用的关键。基因治疗作为一种治疗方法，离大规模应用还有相当长的距离，加强基础研究，注重协作攻关，已成为众多基因治疗专家的共识
The bibliometric method was used to analyze the dynamic changes of 4783 articles published in 42 countries from 1988 to 1997. In the past 10 years, there has been a rapid increase in the literature on gene therapy research. The English literature accounts for 87.87% of all the literature on gene therapy. The United States and Britain have the largest number of published literature on gene therapy in the world at present; accounting for 40.34% 23% of the 23 journals were initially identified as the core journals of gene therapy research; gene therapy methodology and development trend is the main content of the current gene therapy research, the treatment of traditional medicine treatment is the difference between the shrinking, to ensure that the vector into a specific However, the low level of expression of the target gene and the difficulty of obtaining long-term expression in the human body are still the key factors affecting the therapeutic effect and limiting the clinical application of the gene therapy. Gene therapy as a treatment method, there is still a long way to go from large-scale applications, to strengthen basic research, focusing on collaborative research, has become the consensus of many gene therapy experts