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本文对二氧化钛(TiO_2)诱癌实验的180只非纯化Wistar大白鼠进行了病理观察。在22个月实验过程中,二氧化钛未能诱发大白鼠发生肿瘤;体内长期存有超量二氧化钛可引起局部组织纤维化、胃肠道轻度淤血、肝脂肪变性、肺轻度出血等一般性改变。其机理有待进一步研究。
In this paper, 180 non-purified Wistar rats induced by titanium dioxide (TiO 2 ) were examined for pathological changes. Titanium dioxide failed to induce tumors in rats during the 22-month experiment; long-term presence of excess TiO2 in the body can cause local tissue fibrosis, mild gastrointestinal congestion, hepatic steatosis, mild pulmonary hemorrhage, and other general changes. . The mechanism needs further study.