目的:观察吡喹酮对21-d童虫皮层的作用.方法:小鼠于感染日本血吸虫尾蚴达21 d时,ig1剂吡喹酮,并在治疗后1-48 h的不同时间内剖杀取虫,作扫描电镜观察.结果:吡喹酮的剂量为300 mg·kg~(-1)时,宿主体内的21-d童虫示有轻度或中度的皮层褶嵴肿胀、融合、糜烂或破溃,且以盘状感觉器的肿胀为特征.用吡喹酮的较高剂量500 mg·kg~(-1)治疗,虫的体表亦有相似的变化,但较广泛和严重.若每d ig吡喹酮500 mg·kg~(-1),连给3 d,则虫的皮层严重肿、糜烂和剥落,并伴有宿主的白细胞附着.结论:结果表明,吡喹酮对21-d童虫有直接杀死作用. OBJECTIVE: To observe the effect of praziquantel on the 21-d caterpillar cortex.Methods: The mice were infected with pisces of Schistosoma japonicum for 21 days and treated with praziquantel ig 1 at different times of 1-48 h after treatment The results showed that 21-d schistosomes in the host showed mild or moderate ciliary crease swelling and fusion when the dose of praziquantel was 300 mg · kg -1, Erosion or rupture, and is characterized by the swelling of the disk-like sensory organs.With higher doses of praziquantel 500 mg · kg -1, the body surface of worms also had similar changes, but more extensive and severe .If every 500 mg · kg -1 of praziquantel for 3 days, the worm’s cortex was swollen, eroded and exfoliated, accompanied by host’s leukocyte attachment.Conclusion: Praziquantel 21-d squirrels have a direct killing effect.