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目的:了解53例Ⅱ型糖尿病(NIDDM)和50例正常对照者的心率变异性(HRV)的临床意义。方法:应用24小时动态心电图心率变异性频谱分析检查Ⅱ型糖尿病合并或不合并心脏自主神经病变(ANP)的患者。结果:Ⅱ型糖尿病24小时R-R间期标准差(SDNN)(ms),相临正常R-R间期差值超过50ms的百分数(PNN50)显著低于正常人。Ⅱ型糖尿病组R-R间期的总能、高、低频段的幅度均明显低于正常人。结论:HRV是糖尿病心脏自主神经病变(ANP)最敏感而又有效的方法之一。
Objective: To investigate the clinical significance of heart rate variability (HRV) in 53 cases of type 2 diabetes mellitus (NIDDM) and 50 normal controls. METHODS: Patients with type 2 diabetes mellitus complicated with or without cardiac autonomic neuropathy (ANP) were examined by 24-hour Holter heart rate variability spectral analysis. Results: The 24-hour R-R interval standard deviation (SDNN) of type 2 diabetes mellitus (ms) and the percentage of normal R-R interval difference of more than 50ms (PNN50) were significantly lower than that of normal subjects. The total energy, high frequency and low frequency amplitude of R-R interval in type 2 diabetic patients were significantly lower than those in normal subjects. Conclusion: HRV is one of the most sensitive and effective methods for diabetic cardiopulmonary autonomic neuropathy (ANP).