设计并合成了一系列含有反式环己烷结构的C-葡萄糖苷类SGLT2抑制剂,关键步骤是对溴苯甲醚与反式环己烷甲酰氯在无水AlCl3催化下的区域选择性Friedel-Crafts酰基化.所有化合物的结构经过了1H NMR和HRMS的表征.小鼠口服糖耐量实验(OGTT)显示,化合物11a～11d均显示较强的降血糖活性,且11c的活性超过了阳性对照药dapagliflozin,具有良好的开发前景. A series of C-glucoside SGLT2 inhibitors with trans-cyclohexane structure were designed and synthesized. The key step was the regioselective Friedel-Crafts reaction of bromoanisole and transcyclohexanecarbonyl chloride under anhydrous AlCl3 catalysis -Crafts acylation.The structures of all compounds were characterized by 1H NMR and HRMS.The oral glucose tolerance test (OGTT) in mice showed that compounds 11a ~ 11d showed strong hypoglycemic activity, and the activity of 11c exceeded the positive control Medicine dapagliflozin, with good development prospects.