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胶原性结肠炎最初于1976年报道,其特点是:呈慢性水样腹泻并伴有肠粘膜上皮细胞下出现胶原带及非特异性炎性细胞浸润的组织学改变。正常肠粘膜上皮细胞胶原带的厚度为0～5μm,在胶原性结肠炎时胶原带的厚度可达10μm,甚至更多。胶原性结肠炎的临床特点呈多样性,可有腹痛、恶心、体重下降及贫血等,发病机制尚不明确。淋巴细胞浸润,激素治疗有效均支持胶原性结肠炎是自身免疫性疾病。不过要强调的是,尽管80％以上的患者经过强的松治
Collagen colitis was first reported in 1976 and is characterized by chronic watery diarrhea associated with histological changes in collagen bands and nonspecific inflammatory cell infiltration under the intestinal mucosal epithelium. The thickness of normal intestinal mucosa epithelial cells is 0 ~ 5μm, while in colitis, the thickness of collagen zone can reach 10μm or more. Collagen colitis clinical features are diverse, may have abdominal pain, nausea, weight loss and anemia, the pathogenesis is not yet clear. Lymphocyte infiltration, hormone therapy effectively support collagen colitis is an autoimmune disease. However, to emphasize that, although more than 80% of patients after strong Matsushita