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目的探讨脑梗死伴短暂性脑缺血的发病机制的临床意义。方法选取本院治疗的25例脑梗死并伴有短暂性脑缺血患者,作为观察组;另外选取25例脑梗死但没有短暂性脑缺血患者作为对照组。结果观察组基本痊愈6例,显著进步14例,进步5例,治愈率为80%。对照组基本痊愈2例,显著进步11例,进步8例,无变化4例,治愈率为52%。两组患者治愈率相比差异有统计学意义(P<0.01),且两组神经功能评分相比差异具有统计学意义(P<0.01)。结论短暂性的脑缺血会诱导神经组织产生耐受即缺血预处理,可以使大脑采取血管保护机制对抗脑梗死的严重损耗,保护神经功能。
Objective To investigate the clinical significance of the pathogenesis of cerebral infarction with transient cerebral ischemia. Methods Twenty-five patients with cerebral infarction and transient ischemic attack were selected as the observation group. Another 25 patients with cerebral infarction but no transient cerebral ischemia were selected as the control group. Results The observation group basically recovered in 6 cases, significant improvement in 14 cases, progress in 5 cases, the cure rate was 80%. The control group basically recovered in 2 cases, significantly improved in 11 cases, improved in 8 cases, no change in 4 cases, the cure rate was 52%. There was significant difference in cure rate between the two groups (P <0.01), and there was significant difference between the two groups in neurological function scores (P <0.01). Conclusion Transient cerebral ischemia induces the tolerance of nerve tissue, ie ischemic preconditioning, which can protect the nervous system by taking the protective mechanism of blood vessel against the serious loss of cerebral infarction.