简要介绍ＮＯＮＭＥＭ程序的组成、运行环境、估算方法，在微机窗口操作系统下ＮＭ－ＷＩＮ、ＮＯＮＭＥＭ及相关软件的安装和使用，以及ＮＯＮＭＥＭ在常规监测药物群体药动学、特殊生理病理患者群体分析、药物相互作用的定量化研究、药物生物利用度估算、生理模型分析、群体药效学、以及新药开发和临床评价中的应用。 Briefly introduce the composition, operating environment, estimation method of NONMEM program, installation and use of NM-WIN, NONMEM and related software under computer window operating system, as well as NONMEM in routine monitoring drug population pharmacokinetics, special physiological and pathological patient population analysis, Quantitative study of drug interactions, drug bioavailability estimation, physiological model analysis, population pharmacodynamics, as well as the application of new drug development and clinical evaluation.