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目的探讨肝内胆管腺瘤的临床特征、组织来源、病理特点及鉴别诊断。方法观察1例肝内胆管腺瘤的组织形态与免疫组化标记,并结合文献复习。结果肿瘤直径1 cm。镜下见密集排列的分化成熟的小胆管被增生的纤维组织分隔,伴钙化及淋巴细胞浸润。免疫组化:CD56,CK19和CK7(+),Ki-67和p53(-);酸性黏液染色(+)。结论肝内胆管腺瘤罕见,可能来源于胆管周围腺体,病变本质是对局部损伤的反应。临床需与胆管错构瘤、胆管腺纤维瘤、肝内胆管细胞癌等病变相鉴别。
Objective To investigate the clinical features, histological origin, pathological features and differential diagnosis of intrahepatic cholangiocarcinoma. Methods One case of intrahepatic cholangiocarcinoma was observed by histological examination and immunohistochemistry. Results The tumor diameter was 1 cm. Microscopically see the dense arrangement of mature small bile duct hyperplasia of fibrous tissue separation, with calcification and lymphocyte infiltration. Immunohistochemistry: CD56, CK19 and CK7 (+), Ki-67 and p53 (-); Acid mucus staining (+). Conclusion Intrahepatic biliary adenomas are rare, which may originate from the glands around the bile duct. The nature of the lesion is a response to local injury. Clinical needs and bile duct hamartoma, bile duct gland fibroadenoma, intrahepatic cholangiocarcinoma and other lesions identified.