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心跳骤停的初期复苏成功率较高,但对继之而来的脑复苏尚缺乏有效措施,往往使病人遗留脑损害,甚而最终死亡。脑复苏的目的,应使病人恢复智能,有自理生活或工作的能力。一、循环骤停后脑的病理生理改变脑为维持生命和意识活动最重要的器官,脑细胞耗氧量多,代谢率高,能源贮备有限,心跳骤停后,脑内可利用氧即刻耗完,病人在10～15秒钟内神志丧失,脑电图示等电位。30秒钟内源性葡萄糖降至25％,在最初几秒钟,磷酸、肌酸和ATP直线下降,4～5分钟能量贮备全部耗竭,上述改变导致了一系列病理生理变化:包括脑微栓形成,无再流现象(non-refl-
The success rate of initial resuscitation during cardiac arrest is high, but there is still no effective measure for the subsequent recovery of the brain, leaving the patient with brain damage and eventually death. The purpose of brain resuscitation should be to restore the patient’s intelligence, self-care ability to work or work. First, the circulatory arrest after the brain changes in the pathophysiology of the brain to maintain life and consciousness of the most important organs, brain cells, oxygen consumption, high metabolic rate, limited energy reserves, cardiac arrest, the available oxygen depletion of the brain immediately , The patient lost consciousness in 10 to 15 seconds, EEG shows the other potential. 30 seconds after the endogenous glucose dropped to 25%, in the first few seconds, phosphate, creatine and ATP decreased linearly, 4 to 5 minutes all energy depletion, these changes lead to a series of pathophysiological changes: including cerebral micro-embolism Formation, non-reflow phenomenon (non-refl-