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目的探讨肺炎支原体肺炎(MPP)患儿免疫功能变化及匹多莫德对其治疗作用。方法应用流式细胞仪检测2005年3月-2006年12月首都医科大学附属北京友谊医院儿科收治的35例MPP患儿外周血淋巴细胞亚群,另取9例健康儿童作为健康对照组。MPP患儿随机分为匹多莫德治疗组和一般治疗组。匹多莫德治疗组静脉滴注阿奇霉素(10 mg.kg-1.d-1)3~5 d,同时口服匹多莫德(每次400 mg);一般治疗组仅静脉滴注阿奇霉素,剂量和疗程与匹多莫德治疗组相同。比较MPP患儿与健康儿童外周血淋巴细胞亚群的变化及匹多莫德治疗组与一般治疗组治疗后外周血淋巴细胞亚群的变化。应用SPSS 11.2软件对检测结果进行分析。结果 MPP患儿CD4+及CD4+/CD8+比值均低于健康对照组儿童(Pa<0.05),CD19+水平高于健康对照组儿童(P<0.05)。匹多莫德治疗组CD4+、CD4+/CD8+比值较一般治疗组均显著升高(Pa<0.05)。结论 MPP患儿存在T淋巴细胞免疫功能低下和B淋巴细胞异常活化,匹多莫德可提高T细胞数量、增强CD4+辅助性T细胞功能,有助于MPP的恢复。
Objective To investigate the changes of immune function in children with Mycoplasma pneumoniae pneumonia (MPP) and the therapeutic effect of pidotimod. Methods Flow cytometry was used to detect peripheral blood lymphocyte subsets in 35 MPP children admitted to the Beijing Friendship Hospital Affiliated to Capital Medical University from March 2005 to December 2006 and another 9 healthy children were selected as healthy control group. MPP children were randomly divided into pidotimod treatment group and the general treatment group. Pidotimod treatment group intravenous azithromycin (10 mg.kg-1.d-1) 3 ~ 5 d, while oral pidotimod (400 mg each); general treatment group only intravenous azithromycin dose And treatment with pidotimod treatment group the same. The changes of peripheral blood lymphocyte subsets in children with MPP and healthy children and the change of peripheral blood lymphocyte subsets after treatment with pidotimod and general treatment group were compared. Application SPSS 11.2 software to analyze the test results. Results The ratios of CD4 + and CD4 + / CD8 + in children with MPP were significantly lower than those in healthy children (P <0.05). The levels of CD19 + in children with MPP were higher than those in healthy children (P <0.05). The ratio of CD4 +, CD4 + / CD8 + in the Pidotimod group was significantly higher than that in the general treatment group (Pa <0.05). Conclusions The immunosuppressive effect of T lymphocytes and the abnormal activation of B lymphocytes in MPP children may increase the number of T cells and enhance the function of CD4 + helper T cells, which may be helpful for the recovery of MPP.