论文部分内容阅读
HIV-1型感染不同阶段常伴有免疫系统过度活化和免疫细胞衰竭。Treg是具有免疫抑制功能的T细胞亚群,在HIV感染者中,Treg相对数量增多且与CD4+T细胞数量和疾病进展程度相关。共刺激分子PD-1、Tim-3是传递第二信号的负性分子,PD-1、Tim-3分别与其配体结合后可传递抑制信号。研究发现Treg、共刺激分子PD-1、Tim-3以及它们的配体可参与机体免疫调节,在HIV病毒感染中发挥重要作用,与HIV病毒载量及T细胞数量等疾病进展指标有关。
HIV-1 infection at different stages often accompanied by immune system over-activation and immune cell failure. Treg is a subset of T cells with immunosuppressive function. In HIV-infected patients, the relative amount of Tregs is increased and correlated with the number of CD4 + T cells and the degree of disease progression. Costimulatory molecules PD-1 and Tim-3 are negative molecules that transmit the second signal. PD-1 and Tim-3 can respectively transmit inhibitory signals after binding with their ligands. Treg, costimulatory molecules PD-1, Tim-3 and their ligands can participate in the immune regulation of the body, play an important role in HIV virus infection, and HIV viral load and T cell number and other disease progression indicators.