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目的探讨乳腺恶性外周神经鞘肿瘤的临床病理学特征。方法通过光镜及免疫组化方法对1例乳腺恶性外周神经鞘瘤进行观察,同时复习相关文献。结果乳腺恶性外周神经鞘肿瘤呈结节状生长,肿瘤细胞呈梭形或上皮样,核分裂象易见。免疫组化:肿瘤细胞vimentin和S-100弥漫(+),CD56、PGP9.5和bcl-2部分(+),个别细胞CD34和HMB45(+),CK(-)。结论乳腺恶性外周神经鞘肿瘤是一种罕见的肿瘤,需要与乳腺其他间叶性肿瘤鉴别,免疫组化染色对诊断有帮助。
Objective To investigate the clinicopathological features of malignant peripheral nerve sheath tumors in breast. Methods One case of malignant peripheral schwannoma of the breast was observed by light microscopy and immunohistochemistry, and the related literatures were reviewed. Results Malignant peripheral nerve sheath tumor showed nodular growth, tumor cells were spindle or epithelial, mitotic phenomenon is easy to see. Immunohistochemistry: The tumor cells vimentin and S-100 diffuse (+), CD56, PGP9.5 and bcl-2 portions (+), individual cells CD34 and HMB45 (+) and CK (-). Conclusions Breast malignant peripheral nerve sheath tumor is a rare tumor that needs to be distinguished from other mesenchymal tumors in the breast. Immunohistochemical staining may be helpful for the diagnosis.