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患者女,9岁1个月。2个月前因发育提前来我院门诊就诊。体检:双乳增大伴肿块,身高较同龄人增加明显,余未见明显异常。实验室检查:性激素测定:睾酮9.52 nmol/L、泌乳素286.07 m IU/L、孕酮66.11nmol/L(升高),促卵泡生成素0(下降);ACTH+皮质醇测定:皮质醇2.61ug/dl,促肾上腺皮质激素<5.0 pg/ml;肿瘤标志物:神经元特异烯醇化酶18.06 ng/ml(升高),糖抗原CA125、人绒毛膜促腺性激素(HCG+β)、甲胎蛋白、癌胚抗原、糖类抗原均正常。影像学检查:左手骨龄片提示骨龄提前,骨龄约11岁
Female patient, 9 years old and 1 month. 2 months ago because of development to our hospital clinic. Physical examination: breast enlargement with lumps, height increased significantly more than their peers, I did not see significant abnormalities. Laboratory tests: Determination of sex hormones: testosterone 9.52 nmol / L, prolactin 286.07 m IU / L, progesterone 66.11nmol / L (elevated), follicle stimulating hormone 0 (decreased); ACTH + cortisol determination: Cortisol 2.61ug / dl, adrenocorticotropic hormone <5.0 pg / ml; tumor markers: neuronal specific enolase 18.06 ng / ml (elevated), carbohydrate antigen CA125, human chorionic gonadotropin (HCG + Protein, carcinoembryonic antigen, carbohydrate antigen are normal. Imaging examination: left anterior bone age suggest bone age in advance, about 11 years old