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目的:从抗过敏、抗炎症介质释放,以及免疫调节等方面探讨培本方治疗支气管哮喘的作用机理。方法:采用豚鼠过敏性支气管痉挛实验、大鼠同种被动皮肤过敏实验、豚鼠回肠对慢反应物质SRS-A的反应性实验以及二硝基氟苯诱导小鼠耳部迟发性超敏反应实验进行测定。结果:培本方能延缓豚鼠过敏性支气管痉挛的发生时间,抑制炎症介质IM的释放,明显减轻大鼠被动皮肤实验的微血管渗漏;培本方对正常和致敏豚鼠回肠SRS-A的抑制率分别为81.6%和74.2%;对二硝基氟苯诱导的小鼠超敏反应有明显抑制作用。结论:培本方具有良好的免疫调节作用,能抑制IM的释放,减轻气道高反应性,降低微小血管的渗透性。
Objective: To explore the mechanism of treatment of bronchial asthma by anti-allergic and anti-inflammatory mediators and immune regulation. METHODS: Allergic bronchospasm test in guinea pigs, passive cutaneous anaphylaxis test in rats, guinea pig ileum response to slow reaction substance SRS-A, and delayed anaphylactic reaction in ear of mice induced by dinitrofluorobenzene Make measurements. Results:Peibenfang can delay the occurrence of allergic bronchospasm in guinea pigs, inhibit the release of inflammatory mediators IM, significantly reduce the microvascular leakage in passive skin experiments in rats; Peibenfang inhibit SRS-A in ileum of normal and sensitized guinea pigs The rates were 81.6% and 74.2%, respectively; there was a significant inhibitory effect on dinitrofluorobenzene-induced hypersensitivity in mice. Conclusion:Peibenfang has a good immunomodulatory effect, can inhibit the release of IM, reduce airway hyperresponsiveness, and reduce the permeability of microvascular.