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[目的]研究波形蛋白在胃癌中的表达及其临床意义。[方法]采用免疫组化方法检测79例胃癌标本中波形蛋白的表达,并分析其与临床病理参数的关系。[结果]79例胃癌中38例(48.1%)波形蛋白表达阳性。波形蛋白在低/未分化癌中的表达率为60.5%(26/43),显著性高于高/中分化癌(33.3%,12/36)(P<0.05);其在淋巴结转移的胃癌表达率(59.3%,32/54)显著性高于无淋巴结转移者(24.0%,6/25)(P<0.05)。波形蛋白预测胃癌淋巴结转移的敏感度和特异性分别为59.3%、76.0%。[结论]波形蛋白在胃癌中的表达与肿瘤分化类型、淋巴结转移有关,波形蛋白可用于预测胃癌的淋巴结转移状态。
[Objective] To study the expression of vimentin in gastric cancer and its clinical significance. [Method] The expression of vimentin in 79 cases of gastric cancer specimens was detected by immunohistochemistry, and its relationship with clinicopathological parameters was analyzed. [Results] 38 cases (48.1%) of 79 cases of gastric carcinoma had positive vimentin expression. The expression of vimentin in low / undifferentiated carcinoma was 60.5% (26/43), which was significantly higher than that in high / moderately differentiated carcinoma (33.3%, 12/36) (P <0.05) The positive rates of expression (59.3%, 32/54) were significantly higher than those without lymph node metastasis (24.0%, 6/25) (P <0.05). The sensitivity and specificity of vimentin in predicting lymph node metastasis of gastric cancer were 59.3% and 76.0%, respectively. [Conclusion] The expression of vimentin in gastric cancer is related to the type of tumor and lymph node metastasis. Vimentin can be used to predict the status of lymph node metastasis in gastric cancer.