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本文通过对43例球样异型增生和印戒细胞癌的细胞粘液及免疫组织化学研究发现,两类细胞所含三种类型粘液(中性粘蛋白,唾液酸粘蛋白和硫酸粘蛋白)的百分比非常相近,提示两者关系密切。所出现的酸性粘蛋白,尤其硫酸粘蛋白是胃上皮细胞去分化后异常功能的结果。Ⅰ型球样异型增生所含粘液以中性粘液为主;Ⅱ型以酸性粘液为主。球样异型增生细胞中癌胚抗原阳性物质的量(ABC法)随其异型程度的加重而增加,其在细胞内分布形式与印戒细胞癌细胞有同样特点。分析认为,球样异型增生细胞的粘液种类可做为分型的参考指标,癌胚抗原含量的多少可以做为分级的参考指标。
In this paper, the percentage of three types of mucus (neutrinomucin, sialomucin, and sulphate mucin) contained in two types of cells was determined by the study of cellular mucus and immunohistochemistry in 43 cases of bulboid dysplasia and signet-ring cell carcinoma. Very similar, suggesting that the two are closely related. The appearance of acidic mucin, in particular mucin sulfate, is the result of abnormal function after dedifferentiation of gastric epithelial cells. I-type dysplasia contains mucus mainly in neutral mucus; type II mainly in acidic mucus. The amount of carcinoembryonic antigen positive material (ABC method) in the ball-like dysplasia cells increases with its atypicality degree, and its distribution pattern in the cells has the same characteristics as the signet ring cell carcinoma cells. According to the analysis, the mucus type of the spherical dysplasia can be used as a reference indicator for classification, and the amount of carcinoembryonic antigen can be used as a reference index for classification.