论文部分内容阅读
通过１３条犬建立深低温体外循环手术动物实验模型，根据酶学，心肌含水量和电镜６项指标观察其清除氧自由基能力，比较Ｃ９３与临床上常用药—辅酶Ｑ１０的心肌保护作用。再灌注３０′后，Ｃ９３组的血浆丙二醛浓度和血浆肌酸激酶活性均比Ｃ０Ｑ１０组低（Ｐ＜０．０５），而其血浆超氧化物岐化酶却比Ｃ０Ｑ１０组高（Ｐ＜０．０５）。再灌注６０′后，Ｃ９３组的心肌含水量、线粒体肿胀程度均比Ｃ０Ｑ１０低（Ｐ＜０．０５）。结果提示：Ｃ９３的氧自由基清除能力和线粒体修复速度均比Ｃ０Ｑ１０优越，说明Ｃ９３对心肌保护的效果比Ｃ０Ｑ１０好。
The experimental animal models of cryogenic cardiopulmonary bypass were established by 13 dogs. The ability of scavenging oxygen free radicals was observed according to the indexes of enzymology, myocardial water content and electron microscopy. The myocardial protective effect of C93 and coenzyme Q10 was compared. After 30 ’of reperfusion, plasma MDA level and plasma creatine kinase activity of C93 group were lower than those of C0Q10 group (P <0.05), but plasma superoxide dismutase was higher than C0Q10 group (P < 0.05). Myocardial water content and mitochondria swelling in C93 group were lower than those in C0Q10 after 60 ’reperfusion (P <0.05). The results suggest that: C93 oxygen free radical scavenging capacity and mitochondrial repair rate are superior to C0Q10, indicating that C93 myocardial protection better than C0Q10.