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A new type of pseudodipeptide isostere exampled by Phe ψ[CH2CH(OH)]Phe was synthesized from phenylalanine. The H]V protease inhibitory activity (IC50) of Noa-His-Pheψ[CH2CH(OH)]Phe-Ile-Amp was 0. 8 pmol·L-1.
A new type of pseudodipeptide isostere exampled by Phe ψ [CH2CH (OH)] Phe was synthesized from phenylalanine. The H] V protease inhibitory activity (IC50) of Noa-His-Pheψ [CH2CH (OH)] Phe-Ile-Amp was 0. 8 pmol·L-1.