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目的探讨0.1%环孢霉素A滴眼液辅助治疗春季角结膜炎患者的临床疗效。方法选取2013年及2014年3—6月在深圳暨南大学附属深圳市眼科医院确诊的156例双侧春季角结膜炎患者作为研究对象,按随机数字表法将其分为对照组和试验组,各78例。对照组患者单纯使用0.1%盐酸奥洛他定滴眼液进行治疗,试验组患者给予0.1%盐酸奥洛他定滴眼液联合0.1%环孢霉素A滴眼液,比较两组患者的治疗效果、症状与体征改善情况。结果试验组患者治疗的总有效率明显高于对照组,差异有统计学意义(P<0.05);治疗后,试验组患者眼部刺激症状及体征评分均明显低于对照组,差异均有统计学意义(均P<0.05)。结论 0.1%环孢霉素A滴眼液辅助治疗春季角结膜炎患者临床疗效明显,可有效改善患者眼部刺激症状。
Objective To investigate the clinical efficacy of 0.1% cyclosporin A eye drops in adjuvant treatment of patients with vernal keratoconjunctivitis. Methods 156 patients with bilateral spring keratoconjunctivitis diagnosed in Shenzhen Eye Hospital affiliated to Jinan University in Shenzhen from March to June in 2013 and 2014 were selected as research objects and divided into control group and experimental group according to random number table method. Each of 78 cases. Patients in the control group were treated with olopatadine hydrochloride 0.1% alone. Patients in the test group were treated with 0.1% olopatadine hydrochloride eye drops combined with 0.1% cyclosporine A eye drops, and the treatment was compared between the two groups Effect, symptoms and signs of improvement. Results The total effective rate of treatment in experimental group was significantly higher than that in control group (P <0.05). After treatment, the ocular irritation symptoms and signs in experimental group were significantly lower than those in control group Significance (both P <0.05). Conclusion 0.1% cyclosporine A eye drops adjuvant treatment of patients with spring keratoconjunctivitis obvious clinical efficacy, can effectively improve the symptoms of eye irritation in patients.