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目的比较手术前直肠给药米索前列醇和短期口服米非司酮对减少腹腔镜下子宫肌瘤切除术出血的临床疗效。方法选取96例腹腔镜下子宫肌瘤切除术患者,随机分为米索前列醇组、米非司酮组和正常对照组,每组32例。观察3组患者的手术时间、术中出血量,以及米索前列醇组和米非司酮组药物不良反应。结果米索前列醇组、米非司酮组和对照组相比,手术时间明显缩短,术中出血显著减少,差异均有统计学意义(p<0.05);米索前列醇组与米非司酮组相比,手术时间和术中出血量差异无统计学意义(p>0.05),但米索前列醇组的药物不良反应发生率明显<米非司酮组,差异有统计学意义(p<0.05)。结论术前米索前列醇塞肛给药和短期口服米非司酮均能减少腹腔镜下子宫肌瘤切除术中出血,但米索前列醇药物的不良反应发生率明显降低。
Objective To compare the clinical efficacy of preoperative misoprostol and short-term oral mifepristone in reducing laparoscopic myomectomy bleeding. Methods 96 cases of laparoscopic myomectomy patients were randomly divided into misoprostol group, mifepristone group and normal control group, 32 cases in each group. The operation time, intraoperative blood loss and side effects of misoprostol and mifepristone in the three groups were observed. Results Compared with the control group, the misoprostol group and the mifepristone group showed significantly shorter operative time and less intraoperative bleeding, with significant differences (p <0.05). The misoprostol group and the mifepristone group There was no significant difference in operative time and intraoperative blood loss between ketoprofen group and ketamine group (p> 0.05), but the incidence of adverse drug reactions in misoprostol group was significantly lower than that of mifepristone group (p <0.05). Conclusion Preoperative misoprostol anus administration and short-term oral mifepristone can reduce laparoscopic myomectomy bleeding, but misoprostol adverse reaction rate was significantly reduced.