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目的观察氟比洛芬酯注射剂用于肺癌手术后自控镇痛的临床疗效。方法选取我院胸外科肺癌患者88例,随机分为对照组(使用芬太尼镇痛,n=42)和研究组(使用氟比洛芬酯镇痛,n=46),观察2组患者术后0、6、12、24、48 h的血压、心率、血氧饱和度、视觉模拟评分(VAS)、Ramsay镇静评分(RSS)、自控镇痛按压次数以及不良反应的发生率。结果 2组患者的血压、心率、血氧饱和度、VAS、RSS和自控镇痛按压次数等相比差异均无统计学意义,而不良反应中的恶心呕吐在对照组中发生率有31.0%,显著高于研究组的17.4%(P<0.05)。结论氟比洛芬酯注射剂用于肺癌手术后镇痛疗效良好,不良反应轻。
Objective To observe the clinical effect of flurbiprofen axetil injection on controlled analgesia after lung cancer surgery. Methods Totally 88 patients with lung cancer undergoing thoracic surgery in our hospital were randomly divided into control group (fentanyl analgesia, n = 42) and study group (flurbiprofen axetil analgesia, n = 46) Blood pressure, heart rate, blood oxygen saturation, visual analogue scale (VAS), Ramsay sedation score (RSS), number of controlled analgesia and the incidence of adverse reactions were recorded at 0, 6, 12, 24 and 48 h after operation. Results There was no significant difference in blood pressure, heart rate, blood oxygen saturation, VAS, RSS and the number of controlled analgesia press between the two groups. The incidence of nausea and vomiting in adverse reactions in the control group was 31.0% Significantly higher than the study group of 17.4% (P <0.05). Conclusion Flurbiprofen injections are effective in analgesia after lung cancer surgery with mild adverse reactions.