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目的探讨D2-40在下咽癌新生淋巴管形成中的作用及其临床病理意义。方法应用淋巴管内皮特异性标志物D2-40,检测47例下咽癌患者肿瘤组织中及癌旁正常黏膜中的淋巴管密度(LVD),并与临床病理参数进行分析。结果下咽癌肿瘤组织中可观察到新生淋巴管,且肿瘤组织内高表达的LVD与淋巴结转移差异有统计学意义(P<0.05),而与患者年龄、性别、肿瘤分化程度、T分期差异无统计学意义(P>0.05)。结论下咽癌内存在新生淋巴管,且高瘤内LVD和淋巴转移相关,肿瘤可能通过瘤内新生淋巴管进行转移。
Objective To investigate the role of D2-40 in lymphangiogenesis of hypopharyngeal carcinoma and its clinicopathological significance. Methods The lymphatic vessel density (LVD) was detected in 47 cases of hypopharyngeal carcinoma and its adjacent normal mucosa by using D2-40, a marker of lymphatic endothelial cell specificity. The clinicopathological parameters were analyzed. Results Lymphangiogenesis was observed in hypopharyngeal carcinoma, and there was a significant difference between LVD and lymph node metastasis (P <0.05), but not with age, gender, tumor differentiation and T stage No statistical significance (P> 0.05). Conclusion The hypopharyngeal carcinoma has a new lymphatic vessel, and the high intraluminal LVD and lymphatic metastasis related, the tumor may be transferred through the neoplasm lymphatic vessels.