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用四氯化碳致小鼠肝纤维化，分别用促肝细胞生长素（PHGT）和复方丹参注射液进行实验治疗。结果显示：实验治疗组病理显示肝细胞变性坏死经，胶原纤维形成减少，肝细胞再生显著，和复方丹参注射液组相比，无显著差异；透明质酸检测肝纤维化模型组含量明显高于治疗组，而治疗组和对照组相比，无显著差异（P＞0．05）。提示PHGT有抗肝纤维化作用，PHGT对小鼠肝纤维化作用的影响主要是肝细胞得到较好的保护，减轻CCl4造成的肝细胞损伤，终止肝细胞变性坏死，抑制肝纤维化的启动因素，使肝细胞再生。
Mouse liver fibrosis induced by carbon tetrachloride was treated with PHGT and compound Danshen injection respectively. The results showed that: the pathological changes of experimental group showed that hepatic cell degeneration and necrosis, collagen fiber formation reduced and hepatocyte regeneration significantly, compared with compound Danshen injection group, there was no significant difference; the content of hyaluronic acid in liver fibrosis model group was significantly higher than that of compound Danshen injection group Treatment group, while the treatment group and the control group, no significant difference (P> 0.05). Suggesting that PHGT anti-liver fibrosis, PHGT mouse liver fibrosis mainly due to the better protection of liver cells, reduce CCl4-induced liver cell damage, termination of liver cell degeneration and necrosis, liver fibrosis initiation factor , So that the regeneration of liver cells.