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目的观察氯沙坦片对合并高尿酸血症老年高血压患者血压及血压变异性及尿酸代谢的影响。方法 106例合并高尿酸血症老年高血压患者停药2周后,检测血尿酸,采用无创性携带式动态血压监测仪监测动态血压及血压变异性。同时选取50例健康人作对照组观察血压及血压变异性。对合并高尿酸血症老年高血压患者给予氯沙坦(默沙东公司生产科素亚)50mgqd治疗8周,观察治疗前后动态血压及血压变异性及血尿酸的变化。结果治疗前合并高尿酸血症老年高血压患者血压及血压变异性及血尿酸水平明显比对照组高(P<0.05),服用氯沙坦片8周后,合并高尿酸血症老年高血压患者动态血压及血压变异性及血尿酸水平与用药前比较均明显降低(P<0.05)。结论血压变异性增高,氯沙坦在治疗合并高尿酸血症老年高血压患者时不仅具有降压作用,同时还可以降低血尿酸水平,对合并高尿酸血症老年高血压患者应首选氯沙坦。
Objective To observe the effect of losartan on blood pressure and blood pressure variability and uric acid metabolism in elderly hypertensive patients with hyperuricemia. Methods 106 cases of hypertensive patients with hyperuricemia were monitored for serum uric acid after 2 weeks’ withdrawal, and ambulatory blood pressure and blood pressure variability were monitored by noninvasive portable ambulatory blood pressure monitor. At the same time, 50 healthy people were chosen as the control group to observe the blood pressure and blood pressure variability. To treat hyperuricemia in elderly hypertensive patients given Losartan (Merck’s subsidiary Cosuya) 50mgqd treatment for 8 weeks, observed before and after treatment of ambulatory blood pressure and blood pressure variability and changes in serum uric acid. Results Before treatment, the blood pressure and blood pressure variability and blood uric acid level in hypertensive patients with hyperuricemia were significantly higher than those in the control group (P <0.05). After taking losartan for 8 weeks, the patients with hypertensive hyperuricemia Ambulatory blood pressure and blood pressure variability and serum uric acid levels were significantly lower than before treatment (P <0.05). Conclusions The variability of blood pressure is high. Losartan not only has antihypertensive effect but also lowers uric acid level in elderly hypertensive patients with hyperuricemia. Losartan should be the first choice for elderly patients with hyperuricemia .