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目的:探讨HCG、INH-A与妊高征的发病关系及对妊高征的预测价值。方法:随访125例孕14～20周孕妇的妊娠结局,其中发生妊高征者20例。采用ELISA法测定INH-A与β-HCG。结果:妊高征组血浆INH水平(412.24±50.14)ng/L,明显高于正常妊娠组(308.34±68.25)ng/L(P<0.05),重度妊高征患者INH水平高于轻度患者。妊高征组孕妇β-hCG水平(1563.25±320.48)mIU/ml明显高于正常妊娠组(1245.85±296.56)mIU/ml(P<0.05),妊高征组INH-A水平与HCG水平呈正相关(r=0.714,P<0.05)。结论:INH-A、β-HCG水平均能敏感预测妊高征,且妊高征时INH-A和HCG的量呈同步增长,HCG与INH-A联合应用动态检测两者的变化更有利于早期预测妊高征。
Objective: To investigate the relationship between HCG, INH-A and PIH and their predictive value for PIH. Methods: The pregnancy outcome of 125 pregnant women who were pregnant from 14 to 20 weeks was followed up, among which 20 cases were those with PIH. INH-A and β-HCG were determined by ELISA. Results: The level of INH in PIH group was (412.24 ± 50.14) ng / L, significantly higher than that in normal pregnancy group (308.34 ± 68.25) ng / L (P <0.05), and the level of INH in PIH patients was higher than that in mild PIH patients . The level of β-hCG in pregnant women with PIH (1563.25 ± 320.48) mIU / ml was significantly higher than that of normal pregnant women (1245.85 ± 296.56) mlU / ml (P <0.05). INH-A was positively correlated with HCG (r = 0.714, P <0.05). CONCLUSIONS: Both INH-A and β-HCG levels are sensitive to predicting PIH, and the amounts of INH-A and HCG increase synchronously during pregnancy-induced hypertension. The combination of HCG and INH-A can be more beneficial to the dynamic changes of both Early prediction of pregnancy-induced hypertension.