氧是机体新陈代谢和维持生存的必要因素,在某些生理或病理生理条件下,整体或局部缺氧能引起机体出现一系列适应性反应,如红细胞生成素(erythropoietin,EPO)、血管内皮细胞生长因子(vascular endothelium growth factor, VEGF)合成分泌增加,糖酵解途径酶的合成等。这些反应同缺氧诱导细胞产生的一种蛋白质—缺氧诱导因子-1 (hypoxia2inducible actor-1,HIF-1)有关,它可调节一系列基因的转录和表达,以维持机体的正常代谢和功能。 Oxygen is a necessary factor for the metabolism and survival of the body. In some physiological or pathophysiological conditions, global or local hypoxia can cause a series of adaptive reactions in the body, such as erythropoietin (EPO), vascular endothelial cell growth Synthesis and secretion of vascular endothelium growth factor (VEGF), synthesis of glycolytic pathway enzymes and so on. These responses are associated with the hypoxia2inducible actor-1 (HIF-1), a protein produced by hypoxia-induced cells that regulates the transcription and expression of a range of genes to maintain the body’s normal metabolism and function .