药物研究开发是一个十分复杂、涉及到多学科的系统工程。抗肿瘤药物的研究开发尤为如此。由于正常细胞与肿瘤细胞十分相似,抗肿瘤药物的副作用及潜在耐药性就成为了能否开发成功的重要指标。经过多年的研究,抗肿瘤药物得到了长足的发展,相关生存率得到了明显的提高,部分肿瘤可以完全治愈。本栏目从研究开发的视角对一些有代表性 Drug research and development is a very complex system involving multidisciplinary engineering. This is especially true for the research and development of antineoplastic drugs. Since normal cells are very similar to tumor cells, side effects and potential resistance to antitumor drugs have become an important indicator of success. After years of research, antitumor drugs have made considerable development, the relevant survival rate has been significantly improved, some of the tumors can be completely cured. This column from the perspective of research and development on some representative