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新生儿狼疮综合征(NLS)是见于婴儿的一种暂时性胶原综合征。表现为环状红斑、盘状损害、发热、肝脾肿大、贫血、白细胞减少、先天性心脏传导阻滞以及在出生后数周抗核抗体阳性。患儿母亲常患胶原脉管性疾病,有或无症状。近年报告NLS患儿血清抗SS—A、SS—B及RNP抗体阳性,当皮损自行消退后,自身抗体阴转。Franco等曾假设经胎盘传递的自身抗体与NLS有关。本文报告1例NLS。患者女,6周,生后第3周于面部、躯干出现环状红斑,至7个月时红斑自行消退。心电图及血常规检查未见异常。ANA滴度1:320,为小斑点型,抗SS—A抗体滴度1:4,抗SS—B抗体滴度1:8。皮损活检显示真皮上部明显水肿,血管周围有轻度淋巴细胞浸润。患儿母亲既往无症状,亦无胶原病家族史。其异常的实验室检查示γ球蛋白升高,
Neonatal lupus syndrome (NLS) is a temporary collagen syndrome seen in infants. The performance of annular erythema, discoid damage, fever, hepatosplenomegaly, anemia, leukopenia, congenital heart block and anti-nuclear antibodies positive after a few weeks of life. Children with children often suffer from collagen vascular disease, with or without symptoms. In recent years, reports of serum anti-SS-A, SS-B and RNP antibodies in children with NLS positive, when the lesions subside on their own, anti-body autoantibodies. Franco et al. Have assumed that autoantibodies delivered via the placenta are associated with NLS. This article reports a case of NLS. Female patients, 6 weeks, 3 weeks after birth in the face, trunk ring erythema, erythema subsided to 7 months. ECG and blood tests showed no abnormalities. ANA titer of 1: 320, small spot type, anti-SS-A antibody titer of 1: 4, anti-SS-B antibody titer of 1: 8. Skin lesions biopsy showed obvious dermal upper edema, peripheral blood vessels with mild lymphocytic infiltration. Asymptomatic children with past mothers, nor family history of collagen disease. Abnormal laboratory tests showed elevated gamma-globulin,