基因治疗为肿瘤治疗开创了一个新途径，其中自杀性基因疗法是肿瘤基因治疗中的一个重要方法．该方法利用复制缺陷型病毒载体将外源基因导入肿瘤细胞，在肿瘤细胞中外源基因表达出酶蛋白，可以将无毒的前体药物转化为细胞毒药物，选择性地杀伤肿瘤细胞．研究表明，自杀性基... Gene therapy has opened up a new way for cancer treatment. Suicide gene therapy is an important method in gene therapy of cancer. The method utilizes a replication-defective viral vector to introduce foreign genes into tumor cells. Exogenous genes in the tumor cells express enzyme proteins, which can convert non-toxic prodrugs into cytotoxic drugs and selectively kill tumor cells. Studies have shown that suicide based...