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目的:研究11-羰基-β-乙酰乳香酸(AKBA)对盐酸异丙肾上腺素(ISO)诱导大鼠心肌缺血损伤的保护作用机制。方法:SD大鼠随机分为空白组、模型组、AKBA低剂量组、AKBA高剂量组。皮下注射ISO 100 mg·kg-1诱导心肌缺血损伤模型后,测定各组大鼠心电图ST段变化,检测血清的肌酸激酶同工酶(CK-MB)、心肌钙蛋白I(c Tn I)、乳酸脱氢酶(LDH)、丙二醛(MDA)、超氧化物歧化酶(SOD)的含量变化,观察心肌组织病理性改变,检测心肌细胞的凋亡情况。结果:AKBA高剂量组大鼠心电图ST段移位显著低于模型组;AKBA高剂量组能显著降低大鼠血清中心肌酶的CK-MB、c Tn I、LDH;AKBA高剂量组降低大鼠血清中MDA,升高SOD活力;AKBA高剂量组的心肌组织病理损伤小于模型组;AKBA高剂量组抑制心肌缺血损伤中的心肌细胞的凋亡。结论:AKBA组能有效抑制ISO所致心肌缺血损伤,抑制心肌细胞凋亡,对心肌具有保护作用。
AIM: To investigate the protective effect of 11-carbonyl-β-acetyl boswellic acid (AKBA) on isoproterenol-induced myocardial ischemia in rats. Methods: SD rats were randomly divided into blank group, model group, AKBA low dose group and AKBA high dose group. Subcutaneous injection of ISO 100 mg · kg-1 induced myocardial ischemic injury model, ECG changes of ST segment in each group were measured, serum creatine kinase (CK-MB), cardiac troponin I (c Tn I ), Lactate dehydrogenase (LDH), malondialdehyde (MDA) and superoxide dismutase (SOD) were measured. The pathological changes of myocardium were observed to detect the apoptosis of cardiomyocytes. Results: AKBA high-dose group rats ECG ST-segment shift was significantly lower than the model group; AKBA high-dose group can significantly reduce serum myocardial enzymes CK-MB, cTn I, LDH; AKBA high-dose group decreased serum MDA, and increased the activity of SOD. The AKBA high-dose group had less myocardial pathological lesion than the model group. AKBA high-dose group inhibited the apoptosis of myocardial cells during myocardial ischemia. Conclusion: The AKBA group can effectively inhibit myocardial ischemic injury induced by ISO and inhibit cardiomyocyte apoptosis, which has a protective effect on myocardium.