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目的99 mTc-MIBI全身显像对131I治疗分化型甲状腺癌转移灶或复发灶的疗效评价及预后评估。方法患者依次行Tg测定、99 mTc-MIBI全身显像和131I全身显像,三项结果进行对比,并结合其它必要检查及病理分析。结果99 mTc-MIBI全身显像阳性的患者表现为转移灶摄取99 mTc-MIBI的量与摄取131I的量成反比,131I疗效差的转移灶摄取131I量较少,而摄取99 mTc-MIBI量较多,131I疗效较好的转移灶摄取131I量较多,而摄取99 mTc-MIBI量较少;Tg水平超过正常值的患者,均发现有转移灶。结论99 mTc-MIBI显像可观察转移灶变化并相对推测转移灶的细胞分化程度及131I的疗效;联合三种检查可提高转移灶检出率,减少漏诊。
Objective To evaluate the efficacy and prognosis of 99mTc-MIBI whole body imaging in detecting 131I metastasis or recurrence of differentiated thyroid carcinoma. Methods The patients underwent Tg measurement, 99mTc-MIBI whole body imaging and 131I whole body imaging. The three results were compared with other necessary examination and pathological analysis. Results 99mTc-MIBI positive in patients with systemic imaging showed that the amount of 99mTc-MIBI uptake in the metastasis was inversely proportional to the amount of 131I uptake, while the 131I with less effective 131I uptake was less, while the uptake of 99mTc-MIBI was 131I had better therapeutic effect on 131I, while less 99mTc-MIBI was uptake. Metastasis was found in patients with Tg level above normal. Conclusions 99mTc-MIBI imaging can observe the change of metastasis and predict the cell differentiation degree of metastasis and the curative effect of 131I. Combining the three examinations can improve the detection rate of metastasis and reduce the missed diagnosis.