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目的 探讨四肢恶性骨肿瘤术前化疗栓塞价值及其对手术治疗的影响。方法 对 10例恶性骨肿瘤患者保肢手术前行超选择插管化疗栓塞 ,并对栓塞后并发症、肿瘤大体标本及组织学切片、手术切口愈合情况进行观察。结果 全部患者均有明显的栓塞后综合征 (患肢明显肿胀、剧痛等 ) ,2周后消失或明显减轻。局部皮肤坏死 1例。栓塞后 6 2 8d ,瘤体呈不同程度的凝固性坏死 ,其中坏死达 6 0 %以上者 8例 ;术后切口全部Ⅰ期愈合。结论 化疗栓塞术是四肢恶性骨肿瘤保肢术前的一种有效、安全的辅助性治疗方法
Objective To investigate the value of preoperative chemotherapy and embolization of malignant bone tumors of the extremities and its effect on surgical treatment. Methods 10 patients with malignant bone tumors were subjected to superselective catheterization and chemoembolization before limb salvage surgery. The complications after embolization, gross tumor specimens, histological sections, and wound healing were observed. Results All patients had obvious post-embolization syndrome (significant swelling of the affected limb, severe pain, etc.) and disappeared or significantly reduced after 2 weeks. Local skin necrosis in 1 case. After 286 days after embolization, tumors showed different degrees of coagulative necrosis, among which necrosis was more than 60% in 8 cases; postoperative incisions all healed. Conclusion Chemoembolization is an effective and safe adjuvant therapy before limb salvage surgery for malignant bone tumors of extremities