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目的:探讨唾液腺导管癌临床、组织病理学特征、治疗方法及预后。方法:回顾分析6例经病理检查确诊的唾液腺导管癌病例,结合相关文献对其临床发病特点、组织病理学特征、治疗方法和预后等进行分析和探讨。结果:唾液腺导管癌好发于老年人,以腮腺多见,临床上表现为质硬、界限不清的肿块,常伴有神经侵犯症状。主要病理学特征是导管样细胞巢呈实质性、筛孔状和乳头状结构,中心有粉刺样坏死。治疗以手术扩大切除加颈淋巴清扫术为主,术后辅以放疗。术后易复发,颈淋巴结转移率高,常发生远处转移。结论:唾液腺导管癌是一类较少见,恶性程度很高的恶性肿瘤,预后较差。广泛彻底切除肿瘤是提高生存率的关键。
Objective: To investigate the clinical, histopathological features, treatment and prognosis of salivary duct carcinoma. Methods: Six cases of salivary gland ductal carcinoma diagnosed by pathological examination were retrospectively analyzed. Their clinical features, histopathological features, treatment methods and prognosis were analyzed and discussed with related literatures. Results: Salivary gland ductal carcinoma occurred in the elderly, more common in the parotid gland, the clinical manifestations of hard, ill-defined mass, often accompanied by neurological symptoms. The main pathological features of the catheter-like cell nest was a substantial, mesh-like and papillary structures, the center of acne-like necrosis. Treatment of surgical excision plus neck dissection, postoperative radiotherapy. Postoperative recurrence, cervical lymph node metastasis rate, often distant metastasis. Conclusions: Salivary gland ductal carcinoma is a rare malignant tumor with poor prognosis. Extensive and complete removal of the tumor is the key to improving survival.