皮质类固醇(以下简称激素)在支气管哮喘治疗中的适应范围和使用原则是:1.哮喘急性严重发作,可用大剂量控制症状后逐步撤除;2.慢性顽固性哮喘,各种常规治疗均无效时可适当配合β-兴奋剂及茶碱类药合并应用。长期应用激素的副作用已是众所周知的事实。关于激素的平喘效应,其主要作用有以下方面:1.抗炎性效应:激素能稳定细胞膜,对抗机械、化学或过敏反应引起的炎症反应,防止介质释放。2.对环核苷酸的影响:3′—5′磷酸腺苷(cAMP)是调节β受体正常功能的必需物质。激素能增加腺苷酸环化酶的 Corticosteroids (hereinafter referred to as hormones) in the treatment of bronchial asthma in the scope and application of the principles are: 1. Asthma severe acute attack, the symptoms can be controlled with large doses gradually removed; 2. Chronic intractable asthma, various conventional treatment are ineffective Appropriate with β-agonists and theophylline drugs combined application. The long-term side effects of hormones are well known. On the hormone asthma effects, its main role in the following areas: 1. Anti-inflammatory effects: hormones can stabilize the cell membrane against mechanical, chemical or allergic reactions caused by inflammatory reactions to prevent the release of media. 2. Effects on Cyclic Nucleotides: 3’-5 ’cAMP is an essential substance that regulates the normal function of the beta receptor. Hormone can increase adenylate cyclase