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目的 研究神经元特异性烯醇化酶 (NSE)和部分细胞因子在急性脑血管病诊断、病情转归和判断预后的应用价值。方法 应用酶联免疫反应法 (EL ISA)动态测定急性脑血管病病人血清 NSE、NO的水平、变化规律及其相互作用关系 ,利用直线回归分析血清 NSE含量与其他细胞因子的相关性。结果 1脑梗塞和脑出血病人血清 NSE水平显著高于对照组 ,发病后第 1 d最高 ,随着时间的推迟逐渐下降 ,至发病后 2 8d仍明显高于对照组 ,发病后各时间点之间比较无显著性差异。 2脑梗塞和脑出血病人血清NO水平显著降低 ,随着时间的推迟逐渐有升高趋势 ,至发病后 2 8d仍明显低于对照组。结论 NSE、NO可作为急性脑卒中早期诊断、判断病情转归和预后的综合评价指标。
Objective To investigate the value of neuron-specific enolase (NSE) and some cytokines in the diagnosis, prognosis and prognosis of acute cerebrovascular disease. Methods Serum levels of NSE and NO, the changes of serum NO levels and their interaction were determined by enzyme-linked immunosorbent assay (ELISA). The correlation between serum NSE levels and other cytokines was analyzed by linear regression. Results Serum levels of NSE in patients with cerebral infarction and intracerebral hemorrhage were significantly higher than those in the control group at 1 d after onset, and gradually decreased with the lapse of time until the 28th day after onset. The levels of NSE were still significantly higher than those in the control group No significant difference between the two groups. Serum NO levels in patients with cerebral infarction and cerebral hemorrhage decreased significantly, with the delay of time gradually increased, still significantly lower than the control group 28 days after onset. Conclusion NSE and NO can be used as a comprehensive evaluation indicator for the early diagnosis of acute stroke and prognosis.