The stability of the Karmen vortex street in gas-liquid two-phase flow was studied experimentally and theoretically. The values of the parameter h/l characterizing the vortex street structure (I.e., the ratio of the vortex street width to the distance between two vortexes) for a stable vortex street in gas-liquid two-phase flow were obtained for the first time. The parameter h/l was proved to be a variable, not a constant as in single-phase flow. H/l is related to the upstream fluid void fraction. In gas-liquid two-phase fluid flow to form a steady vortex street is more difficult than in a single-phase fluid flow. Because in the unsteady vortex shedding the vortex shedding band frequency is broader than the one in the single phase fluid flow, so it is easier to induce the cross-cylinder resonance than in the single phase fluid flow, and this case should give rise to the attention of engineers.