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目的 :观察益肝浓缩煎剂及其组方中药丹参、黄芪对肝纤维化大鼠肝组织病变的影响 ,并探讨其抗肝纤维化的作用机制。方法 :以皮下注射 4 0 % CCl4 花生油溶液诱导产生大鼠肝纤维化模型 ,并于益肝浓缩煎剂、丹参、黄芪应用治疗前后处死大鼠 ,留取肝组织标本 ,切片并 Masson染色 ,观察胶原纤维增生情况。结果 :益肝浓缩煎剂肝内胶原纤维增生程度明显减轻 ,其疗效优于丹参与黄芪组 :活血化瘀中药有明显抗肝纤维化作用 ;益气健脾中药具有一定的抗肝纤维化作用 ;活血化瘀中药抗肝纤维化作用优于益气健脾中药 ;益肝浓缩煎剂抗肝纤维化作用 ,优于单纯的活血化瘀中药或益气健脾中药。结论 :益肝浓缩煎剂具有良好的抗肝纤维化作用 ,能明显改善肝纤维化大鼠肝脏病变
Objective : To observe the effect of Yigan Concentrate decoction and its formulation on the pathological changes of hepatic tissue in rats with hepatic fibrosis and to explore the mechanism of anti-hepatic fibrosis. METHODS: Rat hepatic fibrosis model was induced by subcutaneous injection of 40% CCl4 peanut oil solution. Rats were sacrificed before and after the treatment of Yigan Concentrate Decoction, Salvia Miltiorrhiza and Astragalus membranaceus. Liver tissue specimens were collected and sectioned and stained with Masson. Collagen fiber proliferation. RESULTS: The proliferation degree of liver collagen fiber in Yigan Concentrate decoction was significantly reduced, and its curative effect was better than that of Dan in Huangqi group. Traditional Chinese medicine has the effect of anti-liver fibrosis; Yiqi and spleen Chinese herbs have a certain anti-hepatic fibrosis effect; The anti-liver fibrosis effect of traditional Chinese medicine is superior to that of replenishing Qi and strengthening the spleen; the anti-hepatic fibrosis effect of Yigan decoction is better than that of simple traditional Chinese medicine for promoting blood circulation, resolving qi and strengthening spleen. Conclusion : Yigan Concentrate Decoction has good anti-hepatic fibrosis effect and can significantly improve the liver pathological changes in liver fibrosis rats