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目的研究食管鳞癌组织中的胰岛素样生长因子-1R(IGF-lR)、血管内皮生长-C(VEGF-C)的表达情况,探讨其意义。方法采用免疫组化法和免疫印迹法对食管鳞癌和癌旁正常食管组织中的胰岛素样生长因子-1R、血管内皮生长因子-C进行检查。结果食管鳞癌组织中胰岛素样生长因子-1R、血管内皮生长因子-C阳性率分别为81.05、67.37,癌旁组织中阳性率为20、5,P<0.0l;食管鳞癌组织中胰岛素样生长因子-1R、血管内皮生长因子-C蛋白条带灰度比值分别为(0.58±0.03)、(0.43±0.05),癌旁组织中分别为(0.43±0.02)、(0.31±0.04),P<0.05。结论食管鳞癌组织中胰岛素样生长因子-1R、血管内皮生长因子-C高表达,是食管鳞癌的发生发展及转移中重要因素。
Objective To investigate the expression of insulin-like growth factor-1R (IGF-1R) and vascular endothelial growth-C (VEGF-C) in esophageal squamous cell carcinoma and to explore its significance. Methods Immunohistochemistry and Western blotting were used to detect the expression of insulin-like growth factor-1R and vascular endothelial growth factor-C in esophageal squamous cell carcinoma and adjacent normal esophageal tissues. Results The positive rates of insulin-like growth factor-1R and vascular endothelial growth factor-C in esophageal squamous cell carcinoma tissues were 81.05 and 67.37, respectively. The positive rates in adjacent non-cancerous tissues were 20.5 and P <0.01. In esophageal squamous cell carcinoma, (0.58 ± 0.03) and (0.43 ± 0.05) respectively in the paracancerous tissues and (0.43 ± 0.02) and (0.31 ± 0.04), respectively, P <0.05. Conclusion High expression of insulin-like growth factor-1R and vascular endothelial growth factor-C in esophageal squamous cell carcinoma is an important factor in the occurrence, development and metastasis of esophageal squamous cell carcinoma.