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目的 探讨与细胞增生有关的细胞因子与BPH发生的相关性。方法 人前列腺分对照组 (正常前列腺 )和实验组 (良性前列腺增生 )。常规组织学染色观察组织形态的变化 ,免疫组织化学方法观察bFGF ,VEGF和EGFR在BPH中的改变。结果 BPH的病理变化呈多类型化。BPH的组织中bFGF和VEGF在间质中明显增加 ;EGFR在腺上皮和间质细胞中都增加明显。结论 在BPH的组织异常增殖中 ,间质的增殖可能与bFGF和VEGF的分泌增多关系密切 ,而EGFR与间质和腺上皮的异常增殖均有关。
Objective To investigate the correlation between cytokines and BPH related to cell proliferation. Methods Human prostate in control group (normal prostate) and experimental group (benign prostatic hyperplasia). The changes of histomorphology were observed by routine histological staining. The changes of bFGF, VEGF and EGFR in BPH were observed by immunohistochemistry. Results The pathological changes of BPH showed multiple types. In BPH tissues, bFGF and VEGF were significantly increased in the stroma; EGFR increased significantly in both gland epithelium and stromal cells. Conclusions In the abnormal proliferation of BPH, the proliferation of stroma may be closely related to the increased secretion of bFGF and VEGF, while EGFR is related to the abnormal proliferation of interstitial and glandular epithelium.