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预先给雄性大鼠肌注丙酸睾丸素(TP)或苯甲酸雌二醇(E_2B)造成高雄或高雌性激素血症,3周后结扎左冠状动脉制作心肌梗塞(MI)模型,MI后继续给药以维持血浆性激素水平,观察性激素对大鼠心肌梗塞范围(IS)及左心室舒缩性能的影响。结果表明;(1)TP及E_2B对IS均无明显影响;(2)大剂量TP可显著改善MI大鼠的左室舒缩性能,而E_2B似对心功能有不利影响;(3)其左室舒缩性能指标(包括±dp/dt max及LVSP)均与血浆性激素水平呈显著的直线相关关系,即与睾酮(T)含量呈正相关,与雌二醇(E_2)含量及E_2/T的比值呈负相关。提示性激素在MI病理生理过程中确起一定作用。
Male rats were given intramuscular injection of testosterone propionate (TP) or estradiol benzoate (E_2B) to cause hyperglycemia or hyperestrogenic hormones. After 3 weeks, the left coronary artery was ligated to produce a myocardial infarction (MI) model, and after MI continued Administration was performed to maintain plasma sex hormone levels, and the effects of sex hormones on myocardial infarction range (IS) and left ventricular diastolic function were observed. The results showed that: (1) TP and E_2B had no significant effect on IS; (2) high-dose TP significantly improved left ventricular systolic and diastolic properties in MI rats, while E_2B appeared to have adverse effects on cardiac function; (3) left The systolic and diastolic performance indicators (including ±dp/dt max and LVSP) showed a significant linear correlation with plasma sex hormone levels, ie positive correlation with testosterone (T) content, estradiol (E_2) content and E_2/T The ratio is negatively correlated. It is suggested that sex hormone plays a role in the pathophysiology of MI.