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我们曾报告2,2,5,5-四甲基-4-羟次甲基四氢呋喃酮-3(Ⅰ)与芳烃邻二胺作用,生成含二个氮原子的七元杂环化合物。Losse等利用某些1,3-二羰基化合物与氨基硫脲或2-烃基取代氨基硫脲作用,得到三氮七元杂环(1,2,4-triazepine)类化合物。但到目前为止,对这类化合物还研究得极少。羟次甲基四氢呋喃酮(Ⅰ)中的羟基易与胺进行缩合,生成相应的Sehiff碱。我们用化合物(Ⅰ)与氨基脲在室温下反应,生成相应的缩氨脲(Ⅱ)。(Ⅱ)在酸性介质中加热时,即环化为相应的三氮七元杂环化合物(Ⅲ)。
We have reported that 2,2,5,5-tetramethyl-4-hydroxymethyltetrahydrofuranone-3 (Ⅰ) interacts with an aromatic o-diamine to form a seven-membered heterocyclic compound containing two nitrogen atoms. Losse et al utilize certain 1,3-dicarbonyl compounds to react with thiosemicarbazides or 2-hydrocarbyl-substituted thiosemicarbazones to give 1,2,4-triazepine compounds. But so far, very few studies have been done on these compounds. The hydroxyl groups in the hydroxymethyltetrahydrofuranone (I) are easily condensed with the amine to form the corresponding Sehiff base. We use compound (I) and semicarbazide to react at room temperature to form the corresponding urea (Ⅱ). (II) is cyclized to the corresponding triazacycloheterocyclic compound (III) when heated in an acidic medium.