论文部分内容阅读
目的总结血清甲状腺球蛋白(thyroglobulin,Tg)水平对分化型甲状腺癌(differentiated thyroid cancer,DTC)的术前诊断及术后监测的价值。方法采用文献复习的方法对血清Tg水平在DTC术前诊断和术后监测中的价值予以分析总结。结果 1术前血清Tg水平对甲状腺结节的良恶性诊断有一定的价值,尤其对细针穿刺病理学检查无法明确诊断的甲状腺滤泡状癌及何氏(Hürthle)细胞癌的诊断具有很高的特异性,并且血清Tg水平与DTC原发灶的大小及是否有远处转移均有密切的联系。2术后血清Tg水平升高是判断DTC复发及转移的重要依据,但需注意Tg合适临界值的确立、不同方法测定结果的差异、对假阳性及假阴性的准确判断,以及适当结合其他影像学检查。结论血清Tg水平在DTC术前诊断及术后监测中均起非常重要的作用,应引起临床医生的高度重视。
Objective To summarize the value of serum thyroglobulin (Tg) in preoperative diagnosis and postoperative monitoring of differentiated thyroid cancer (DTC). Methods The literature review method of serum Tg levels in DTC preoperative diagnosis and postoperative monitoring of the value be analyzed and summarized. Preoperative serum Tg levels of benign and malignant thyroid nodules have some value, especially for fine needle aspiration biopsy thyroid follicular carcinoma and Hürthle cell carcinoma diagnosis is very high Specificity, and serum Tg level and DTC primary tumor size and whether there is a distant metastasis are closely linked. 2 postoperative serum Tg is an important basis for judging the recurrence and metastasis of DTC, but should pay attention to the establishment of Tg critical value, the difference between the results of different methods to determine the false positive and false negative, as well as the appropriate combination of other images School inspection. Conclusion The serum Tg level plays a very important role in the preoperative diagnosis and postoperative monitoring of DTC, which should be taken seriously by clinicians.