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笔者于2001年4月至2002年3月在日本新泻大学医学部产科与妇人科教室进修1年。进修期间的主要研究方向为肿瘤的基因诊断与治疗。包括:①GST-π基因转染人脐血造血干细胞对其抗肿瘤药物耐药性影响的研究;②I1-6基因转染人造血干细胞的研究;③耐药基因单核苷酸多态性分析与卵巢癌预后关系的研究。人类脐血中含有大量造血干细胞,可以代替骨髓进行移植。GST-π基因转染人脐血造血干细胞能提高对铂类、烷化剂、阿霉素、足叶乙甙等的耐药性。将其移植体内,可提高骨髓对相应化疗药物的耐药性,对骨髓产生保护作用,从而可加大化疗剂量,提
The author from April 2001 to March 2002 in Japan’s Niigata University School of Medicine obstetrics and gynecology classroom training for 1 year. During the training of the main research directions for the diagnosis and treatment of cancer genes. Including: ①GST-π gene transfection of human umbilical cord blood hematopoietic stem cells on the anti-tumor drug resistance research; ②I1-6 gene transfection of human hematopoietic stem cells; ③ resistance gene single nucleotide polymorphism analysis and Prognosis of ovarian cancer. Human umbilical cord blood contains a large number of hematopoietic stem cells, bone marrow transplantation can be replaced. GST-π gene transfection of human umbilical cord blood hematopoietic stem cells can increase resistance to platinum, alkylating agents, doxorubicin, etoposide and so on. Will be transplanted into the body, can improve bone marrow resistance to the corresponding chemotherapeutic drugs, have a protective effect on bone marrow, which can increase the dose of chemotherapy, mention