胰腺纤维化是胰腺炎、胰腺癌主要的病理学特征。活化的胰腺星状细胞(pancreatic stellate cell,PSC)是胰腺炎致胰腺纤维化的主要效应细胞,在胰腺炎与胰腺癌的纤维化进程中发挥重要作用。近期研究发现,PSC也存在于糖尿病动物胰岛中,可能参与糖尿病胰岛纤维化及β细胞衰竭的发展进程。现就PSC与胰腺炎、胰腺癌及糖尿病关系的研究进展作一综述。 Pancreatic fibrosis is a major pathological feature of pancreatitis and pancreatic cancer. Activated pancreatic stellate cells (PSCs) are the main effector cells of pancreatic fibrosis induced by pancreatitis and play an important role in the process of fibrosis of pancreatitis and pancreatic cancer. Recent studies have found that PSC also exists in the islets of diabetic animals, which may be involved in the development of diabetic islet fibrosis and β-cell failure. Now on the PSC and pancreatitis, pancreatic cancer and diabetes research advances are reviewed.