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戊型病毒性肝炎(HE)在世界上首次记载始于1955～1956年在印度新德理发生的急性肝炎爆发流行,共发病97000例,1980年Wong等证实为经肠道传播的非甲非乙肝炎(HNANB),1983年Balayan等首次用HE病人的粪便提取液,经口感染1名志愿者获得成功。1989年Reyes等应用分子克隆技术获得本病毒基因克隆,并在同年9月东京国际肝炎学术会上正式将ET-HNANB命名为HE,其病原体称为HEV。我国新疆南部地区1983～1986年曾持续23个月HE暴发流行,累及人口达10余万人。至目前止,已有6个省市自治区报告HE流行。近年来本省已有HE病例出现,呈散发性,现将1992年4月～1994年5月作者所接触的125例住院HE进行临床分析。 一、材料与方法 本组125例均经采用新加坡诊断生物制品公司提供的试剂盒,用ELISA方法检测HEV IgG,结果全部阳性。同时检测抗HAV IgM、抗HBc
Hepatitis E virus (HE) is the first recorded in the world from 1955 to 1956 in New Delhi, India, the incidence of acute hepatitis outbreak, a total of 97,000 cases of onset, confirmed in 1980 Wong and other intestinal transmissible non-A non Hepatitis B (HNANB), Balayan 1983, for the first time with HE patient excrement extract, oral infection of a volunteer to be successful. 1989 Reyes and other molecular cloning technology to obtain the virus gene cloning, and in September the same year Tokyo International Hepatitis Society officially named ET-HNANB HE, the pathogen called HEV. The epidemic of HE outbreak in China’s southern part of Xinjiang from 1983 to 1986, which lasted 23 months, involved more than 100,000 people. So far, six provinces have reported HE epidemic. In recent years, HE cases have appeared in this province, showing sporadic, now in April 1992 ~ May 1994 contact with 125 cases of hospitalized HE clinical analysis. First, the material and methods The group of 125 cases were used by Singapore Diagnostics Biological Products provided by the kit, ELISA method for the detection of HEV IgG, the results were all positive. Simultaneous detection of anti-HAV IgM, anti-HBc